【摘要】 男性乳癌临床罕见,但它在全球的发病率持续增长。由于样本量少,缺乏随机化临床试验,很多研究借鉴于女性乳癌,但男性乳癌与女性乳癌之间存在诸多差异。男性发病年龄比女性晚。对该病的关注及重视不够,使得就诊时肿块直径较大,进展期多见,多有腋窝淋巴结转移,预后不佳。男性乳癌以浸润型导管癌多见,小叶癌罕见,不同于女性乳癌。无痛性肿块常发生于乳晕下,局部浸润症状多见(累及皮肤及乳头),女性乳癌常发生于乳房外上象限。ER、PR受体阳性率高,他莫西芬是首选的一线激素治疗药物。更多还原

【Abstract】 Male breast cancer is a rare disease,but the incidence has increased all over the world.Because absent of randomized clinical trials,many principles are derived from female breast cancer.But they are different from breast cancer in females.Men tend to be diagnosed at an older age than woman.The lack of awareness of this disease leads to its detection at a large size lump,advanced stage and several axillary nodes involved.All are associated with a worse outcome.Most of the male breast cancer presents with invasive ductal histology.In contrast to female breast cancer,lobular carcinoma is very seldom.The painless lump of male breast cancer is commonest located in the subareolar region,but female breast cancer is usually in the upper outer quadrant.More signs of part skin and /or nipple involvement are showed.Because generally has a higher rate of estrogen /progesterone hormone receptor positive than carcinoma of the female breast,and tamoxifen is the standard adjuvant therapy.更多还原