【摘要】 背景:人工硬脑膜因资源丰富、易于制备、无抗原性、与下方的脑组织不发生粘连并易于裁剪及缝合等特点被广泛应用。目的:综述人工硬脑膜修补材料在神经外科的应用进展。方法:应用计算机检索中国知网数据库、中国期刊全文数据库、中国博士学位论文全文数据库、中国优秀硕士学位论文全文数据库、中国生物医学文献服务系统(CBM)及维普数据库有关人工硬脑膜治疗颅脑缺损的文献,中文检索词"人工硬脑膜,硬脑膜修补,颅脑损伤"。检索文献量总计146篇。最终纳入符合标准的文献23篇。结果与结论:在硬脑膜缺损修补方面,过去多采用自身组织修复,但由于其取材来源局限,并可能造成新的创伤,增加患者苦痛等缺点使其在临床运用有一定的局限。所以对于小的缺损,可以采用自体组织如肌筋膜等进行修复,而对于大面积硬脑膜缺损的修补,往往需要采用人工硬脑膜替代材料。在神经外科,用替代材料修补缺损的硬脑膜对于维持解剖学的完整和保护脑组织是十分必要的。人工硬脑膜在修补硬脑膜缺损的实际应用中比自体膜有更大优越性。但由于其存在组织相容性等不可避免的缺点,硬脑膜修复材料仍需进一步研究。更多还原

【Abstract】 BACKGROUND:Artificial dural repair materials are widespreadly used because they have numerous features,such as abundant resources,no antigenicity,do not adhere to the inferior brain tissues,are easy to prepare,clip and suture.OBJECTIVE:To summarize the application progress of artificial dural repair materials in neurosurgery.METHODS:A computer-based online search of China National Knowledge Infrastructure,China Journal Full-text Database,China Doctoral Dissertations Full-text Database,Chinese Master’s Theses Full-text Database,China Biology Medicine Database and VIP database was performed for articles related to brain injury repair using artificial dura mater,with the key words of "artificial dura mater","dura mater repair" and "brain injury".A total of 146 articles were collected after primary search,23 of them were retained in the end according to the inclusion criteria.RESULTS AND CONCLUSION:In the past,self tissue repair has been widely used to repair the dura mater defects;but it has certain limitations in the clinical application because of its own disadvantages,such as limited sources,the possibility to cause a new wound and increasing pain to patients.Therefore,self-tissue,such as muscular fasciae,can be used to repair small defects;while for the large dural defects,artificial dura substitute materials are often required.Using alternative materials to repair dura defects is essential for the maintenance of anatomical integrity and brain protection in neurosurgery.Artificial dura mater has superiority over the autologous dura mater in the practical application of dura mater defects repair.However,due to the existence of histocompatibility and other inevitable shortcomings,dural repair materials still need to be further studied.更多还原