【摘要】 目的分析近两年本院患者中分离的金黄色葡萄球菌的耐药情况,为临床合理使用抗菌药物提供依据。方法用湖南天地人公司TDR-200B微生物分析系统进行鉴定和药敏试验,WHONET5.3软件统计分析结果。结果 98株金黄色葡萄球菌中耐甲氧西林金黄色葡萄菌(MRSA)65株(66.3%),主要来源于痰、伤口分泌物、脓等。检出的MRSA除对万古霉素和替考拉宁敏感,对米诺环素和氯霉素耐药率较小(24.6%和27.7%),对利福平的耐药率为52.3%外,对其他抗菌药物耐药率均大于80.0%,且耐药率均高于甲氧西林敏感金黄色葡萄球菌。结论临床分离的金黄色葡萄球菌,MRSA对多种抗菌药物耐药率较高,许多MRSA菌株为多重耐药菌,实验室应加强对MRSA的耐药监测,以便合理使用抗菌药物。更多还原

【Abstract】 Objective To analyze the drug resistance of Staphylococcus aureus isolated from the patients in the People’s Hospital of Guiyang County in the last two years,and to provid a basis for rational use of antimicrobial agents in clinic.Methods Identification and antimicrobial susceptibility test of Staphylococcus aureus were determined with TDR-200B Microbiological Analysis System.The results were analyzed by WHONET5.3 software.Results Among the 98 strains of Staphylococcus aureus,65 strains(66.3%) were methicillin-resistant Staphylococcus aureus(MRSA),mainly from sputum,wound exudates and pus,etc.The detected MRSA were sensitive to vancomycin and teicoplanin.Their resistance rates to chloramphenicol,minocycline and rifampin were 24.6%,27.7% and 52.3% respectively.The drug resistance rates of MRSA to other antimicrobial agents were all greater than 80% and were higher than those of methicillin-susceptible Staphylococcus aureus.Conclusions Among Staphylococcus aureus isolated in clinic,MRSA has high resistance rates to many antimicrobial agents.Many MRSA strains are multi-drug resistant.The drug resistance of MRSA should be closely monitored in laboratories for the benefit of rational use of antimicrobial agents in clinic.更多还原