【摘要】 目的:了解乙肝病毒e抗原(HBeAg)阴性和阳性慢性乙型肝炎及相关肝病患者临床和病毒学特点。方法:对421例慢性乙型肝炎及相关肝病患者进行回顾性调查,分析HBeAg阴性和阳性的乙肝患者流行病学、病例构成、肝功能、HBV-DNA载量及乙肝前S1抗体(PreS1Ag)等指标的差异。结果:HBeAg阴性组发病率高,占57.96%,高于HBeAg阳性组,其重型肝炎、肝硬化、肝癌构成及肝功能损害指标高于HBeAg阳性组,HBV-DNA载量、PreS1Ag阳性率低于HBeAg阳性组。结论:HBeAg阴性的慢性乙型肝炎及相关肝病发病率高,进展快,预后差,是今后防治慢性乙型肝炎的重点。更多还原

【Abstract】 Objective:To investigate the clinical characteristics of Hepatitis B antigcny(HBeAg) negative andHBeAg-positive chronic hepatitis B and liver disease correlative.Methods:A total of 421 hospitalized chronic hepatitis B and liver disease correlative were analyzed retrospectively.The epidemiology,composition of cases,hepatic function,HBV-DNA levels and PreS1Ag et al of HBeAg-negative and HBeAg-positive chronic hepatitis B were compared.Results:Among the cases,244(57.96%) were HBeAg-negative.The age of the HBeAg-negative group was(43.51±14.48),the lever of the age was higher than the HBeAg-positive group.The proportion of gravis type hepatitis,liver cirrhosis and liver cancer in HBeAg-negative group was higher than HBeAg-positive group.But the lever of HBV-DNA and the rate of PreS1Ag-positive in HBeAg-negative group was lower than HBeAg-positive group.Conclusion:The attack rate of HBeAg-negative chronic hepatitis B and liver disease correlative was high,the advancement was quick.In the future the prevention and cure for the HBeAg-negative chronic hepatitis B and liver disease correlative is emphasis in our work.更多还原