【摘要】 糖尿病是一种由胰岛素分泌缺陷和(或)胰岛素作用缺陷引起的高血糖症性代谢疾病。自Edmonton临床试验取得成功后,胰岛移植成为一种新型治愈糖尿病的方法。但胰岛β细胞在体外分离过程中极易发生凋亡或死亡,且长期的体外培养或冷冻储存也容易令其胰岛素分泌功能逐渐丧失。因此,有效维持或改善β细胞的成活率及功能对胰岛移植的成功至关重要。对胰岛β细胞的体外保护方法进行阐述,并对其研究前景进行展望。更多还原

【Abstract】 Diabetes mellitus is a metabolic disease with the symptom of hyperglycemia caused by insulin secretion deficiency and(or) insulin action defects.Since the Edmonton clinical trials,islet transplantation has been considered as a new cure for diabetes.However,islet β cells are vulnerable to apoptosis or death during the isolation process.Furthermore,long time culture or cryopreservation in vitro could gradually deprive the functional activity of β cells.Therefore,maintaining or improving the survival and function of β cells is critical to the success of islet transplantation.In this review,protective methods of islet β cells in vitro had been described,and the research prospects outlined as supplement.更多还原