【摘要】 【目的】通过观察中药羌银解热汤对临床拟诊流行性感冒(简称流感)患者外周血T细胞亚群水平的影响,探讨该中药组方抗流感病毒的机制。【方法】选择急诊临床拟诊为流感的患者91例,参照随机数字表随机分为羌银解热汤组46例和日夜百服咛组45例,观察2组患者的临床疗效,检测并比较2组患者治疗前后外周血CD3+、CD4+、CD8+T细胞水平。【结果】(1)羌银解热汤组的痊愈率和总有效率分别为30.43%和82.61%,日夜百服咛组分别为13.33%和62.22%,羌银解热汤组的痊愈率、总有效率和总疗效均优于日夜百服咛组,差异均有统计学意义(P<0.05或P<0.01)。(2)治疗后,2组患者的CD3+、CD4+、CD8+T细胞水平均较治疗前显著提高(P<0.05)。治疗后2组比较,羌银解热汤组患者的CD3+、CD4+、CD8+T细胞水平显著高于日夜百服咛组,差异均有统计学意义(P<0.05)。【结论】羌银解热汤对临床拟诊流感患者有显著疗效,作用机理可能与其能有效提高流感患者外周血CD3+、CD4+、CD8+T细胞水平,增强机体免疫力有关。更多还原

【Abstract】 Objective To observe the influence of Qiang Yin Heat-clearing Decoction on peripheral T lymphocyte subgroup levels in influenza patients,and to explore its anti-influenza virus mechanism.Methods Ninety-one influenza patients admitted in the emergency department of Zhongshan Municipal Hospital were randomized into treatment group(N=46) and control group(N=45).The treatment group was given Qiang Yin Heat-clearing Decoction orally and the control group was given Bufferin Cold orally.The therapeutic effect was evaluated after treatment,and the peripheral CD3 +,CD4 +,CD8+ T lymphocyte levels were detected before and after treatment.Results(1) The cure rate and total effective rate were 30.43% and 82.61% in the treatment group,and were 13.33% and 62.22% in the control group,respectively.The cure rate,total effective rate and total therapeutic effect in the treatment group were superior to those in the control group(P<0.05 or P<0.01).(2) After treatment,the peripheral CD3 +,CD4 +,CD8+ T lymphocyte levels were increased in the two groups(P<0.05 compared with those before treatment),and the levels were higher in the treatment group than those in the control group(P<0.05).Conclusion Qiang Yin Heat-clearing Decoction exerts certain therapeutic effect in the treatment of influenza,and its possible anti-influenza virus mechanism is related with the increase of peripheral CD3 +,CD4 +,CD8+ T lymphocyte levels and with the enhancement of immunity.更多还原