【摘要】 目的探讨α-2b干扰素联合苦参素治疗慢性乙型肝炎临床疗效。方法 90例慢性乙型肝炎患者,随机分为治疗组47例,对照组43例。治疗组采用α-2b干扰素500万U肌注,隔日1次,疗程6个月,同时加用苦参素胶囊200mg,每日3次,疗程6个月。对照组单用α-2b干扰素,剂量、用法及疗程相同。疗程结束时,观察两组患者肝功能丙氨酸转移酶(ALT)复常率、HBeAg、HBV-DNA阴转率及血清肝纤维化等指标变化。结果治疗组和对照组患者ALT复常率分别为80.9%和60.5%,HBeAg阴转率分别为59.6%和34.9%,HBV-DNA阴转率分别为63.8%、41.9%,两组比较差异均有统计学意义(P<0.05)。治疗组血清透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、IV型胶原(IV-C)、层粘蛋白(LN)指标均较对照组降低,差异均有统计学意义(P<0.05或P<0.01)。结论α-2b干扰素联合苦参素治疗慢性乙型肝炎优于单一干扰素治疗,能较好地抑制病毒复制、改善肝功能和抗肝纤维化等。更多还原

【Abstract】 Objective To investigate the clinical effect of interferon α-2b combined with Oxymatrine capsules in the treatment of chronic hepatitis B.Methods 90 patients with chronic hepatitis B were randomly allocated into two groups.47 patients in treatment group were given interferon α-2b 5×10 6 U i.m.qod up to 6 months;combined with Oxymatrine capsules 200 mg p.o.tid for 6 months.43 patients in control group were given the same dose of interferon α-2b as above only.After completion of therapy,the serum ALT recovery rate,the HBeAg negative rate,the HBV-DNA negative rate and liver fibrosis of the two groups of patients were compared.Results Serum ALT decreased to normal range in 80.9% and 60.5% of the patients in treatment group and in control group,respectively.HBeAg turned to negative in 59.6% of the patients in treatment group compared with 34.9% in control group.HBV-DNA turned to negative in 63.8% and 41.9% of the patients in the two groups,respectively.The two groups differ significantly(P <0.05).Levels of serum hyaluronidase(HA),pro-collagen type Ⅲ(PC-Ⅲ),collagen type Ⅳ(Ⅳ-C) and laminin(LN) were significantly different between the two groups(P<0.05,P<0.01).Conclusions Interferon α-2b combined with oxymatrine capsules is better than interferon α-2b alone in the treatment of chronic viral hepatitis B.It can inhibit HBV replication more effectively and improve liver function and prevent hepatic fibrosis.更多还原