【摘要】 目的分析北京市153株沙门菌分离株多重耐药情况和流行病学特征,为本地区的沙门菌临床合理用药提供依据。方法通过WHO全球沙门菌监测系统及北京市肠道门诊监测系统分离到的153株沙门菌进行生化鉴定、血清分型同时采用K-B纸片法检测药物敏感性,并统计相关流行病学资料。结果 153株沙门菌药敏结果显示多重耐药菌株为61株(39.87%),其中以肠炎沙门菌和鼠伤寒沙门菌为主要的多重耐药血清型。61株多重耐药菌株中以耐4～5种抗生素为主,占55.74%(34/61);主要耐药模式为耐五种抗生素:氨苄西林、链霉素、磺胺异噁唑、萘啶酸、四环素,占27.87%(17/61)。61株多重耐药菌株中男女比例1.54:1,以男性为主。年龄分布以0～10岁(占24.59%)和21～30岁(占27.87%)为主。结论沙门菌多重耐药性分析提示耐药模式更加多样化,耐药人群趋于年轻,进一步强调合理选择及使用抗生素的必要性。更多还原

【Abstract】 Objective To understand the multidrug resistant(MDR)and epidemiological characteristics of 153 Salmonella strains isolated in Beijing.Methods A total of 153 isolates recovered from the WHO Global Salmonella Surveillance system and enteroclinic Surveillance system were identified by biochemical tests and serotyping,Antimicrobial resistance was tested using the Kirby-Bauer method.Results Sixty-one out of the 153 Salmonella strains were multidrug resistant(39.87%),Salmonella enteritidis and Salmonella typhimurium were the main multidrug resistant serotypes.Thirty-four strains(55.74%)were resisted to four or five antibiotics,the main resistance pattern was resistant to five antibioticsiinclusing ampicillin,streptomycin,sulphafurazole,nalidixic acid,tetracyclin,accounting for 27.87%(17 / 61).The ratio of male to female of the 61 multidrug resistance strains was 1.54:1 and mainly distributed in the age group of under years(24.59%)and the age group of 21-30 years old(accounting for 27.87%).Conclusion It shows that the multidrug resistant patterns of Salmonella are diverse and the drug resistanct population are diverse and drug-resistant populations tend occurring to the young age group.Thus reasonable selection of antibiotics for clinical purpose is indicated.更多还原