【摘要】 目的观察加味补阳还五汤对缺血性卒中患者急性、亚急性期和恢复期血浆同型半胱氨酸(Hcy)、血清C反应蛋白(CRP)和Barthel指数评分的影响。方法缺血性卒中患者(82人)随机分为补阳还五汤治疗组(42人)、对照组(40人),疗程4周,随访180天,分别在治疗14、28、90天后检测两组患者Hcy、CRP,进行Barthel指数评分。180天后统计心脑血管事件发生率。结果 Hcy:治疗14天后治疗组较治疗前明显下降(P<0.01),对照组治疗28天后较治疗前下降,但治疗组明显优于对照组(P<0.01);CRP:14天治疗组较治疗前明显下降(P<0.05),对照组治疗28天后较治疗前下降,但治疗组明显优于对照组(P<0.01);Barthel指数评分:治疗14天后治疗组治疗前、后差异明显,后者提高(P<0.01),治疗28天后两组患者均提高,但治疗组优于对照组(P<0.05,P<0.01)。90天后治疗组各项指标均优于对照组(P<0.01);180天时治疗组患者出现1例(2.38%)心脑血管复发事件;对照组患者出现3例(7.5%)心脑血管复发事件,两组之间差异有统计学意义(P<0.05)。结论加味补阳还五汤对缺血性卒中急性期和亚急性期的治疗有效,恢复期能够降低脑血管事件复发率。更多还原

【Abstract】 Objective To explore the influence modified Buyanghuanwu decoction on patients with ischemic stroke evaluated by the levels of Homocysteine(Hcy),C-reaction protein(CRP) and Barthel index score.Methods Randomly diveded 82 patients with ischmic stroke into two groups:Buyanghuanwu group(42 patients)and Control group(40 patients);treated for 4 weeks as a course and followed-up for 180 days and the Hcy and CRP were detected at 14th d,28th d and 90th d,respectively,after treatment,and then the Barthel index score was evaluated.The events of incidence for cadiocerebralvacular diseases were calculted after 180 d.Results Hcy:the level of Hcy was significantly reduced in Buyanghuanwu group than control group after 14ds treatment(P<0.01).The Hcy level in control group treated by routine treatment for 28ds was reduced when compared with itself before treatment or Buyanghuanwu group(P<0.05 or P<0.01).CRP:the level of CRP was significantly reduced in Buyanghuanwu group than control group after 14ds treatment(P<0.01).The Hcy level in control group treated by routine treatment for 28ds was reduced when compared with itself before treatment or Buyanghuanwu group(P<0.05 or P<0.01)Barthel index score:the score was significantly increased in Buyanghuanwu group than control group after 14ds,28ds and 90ds treatment,respectively(P<0.01,P<0.05 and 0.01).There was 1case(2.38%) and 3 cases(7.5%) of cadiocerebralvacular recurrence events appeared in Buyanghuanwu group and control group,respectively,at 180th d after treatment,and there showed significant difference between two groups(P<0.05).Conclusion Modified Buyanghuanwu Decoction shows effectiveness on acute and subacute ischemic stroke and reduces the recurrence rate of adiocerebralvacular events in the stage of restoration.更多还原