【摘要】 目的定量研究不同年龄健康人脑结构扩散张量成像(DTI)的T2-WT参数图的特点及其与年龄的关系。方法健康右利手志愿者58人,年龄22～76岁,按年龄分为青年(≤40岁)组30人,中老年(>40岁)组28人,采集人脑常规MRI及DTI图像,经后处理得到DTI的三种参数图:T2-WT、分数各向异性(FA)及平均扩散系数(MD)图,使用FA图及MD图设置兴趣区,测量人脑10个部位的参数值,定量分析不同年龄组T2-WT参数值的特点及其与年龄的关系。结果青年组T2-WT值在桥脑、大脑脚、内囊前肢、半卵圆中心和豆状核左侧>右侧,P=0.000～0.024,差异有统计学意义。中老年组,半卵圆中心T2-WT值左侧>右侧,P=0.042,差异有统计学意义。两组比较,除侧脑室外,其他部位中老年组的T2-WT值均低于青年组,T2-WT值在桥脑、大脑脚投射纤维、内囊前肢、内囊膝部、内囊后肢和豆状核六个部位与年龄有负相关关系,P=0.000～0.038,差异有统计学意义。结论健康人脑结构T2-WT值在桥脑、大脑脚投射纤维、内囊前肢、内囊膝部、内囊后肢和豆状核与年龄有负相关关系,T2-WT图的左右对称性在中老年人脑表现更明显。更多还原

【Abstract】 Objective To quantitatively analysis the DTI T2-weighted trace(T2-WT) parameter map in different age of healthy human brain and its relation to age.Methods Data were acquired in fifty-eight healthy right-handed volunteers(22-76 years).28 subjects in middle-old age group(>40years) and 30 subjects in young group(≤40years).All subjects underwent diffusion tensor imaging(DTI) and conventional MRI with a GE 3.0T magnetic resonance system.Three DTI parameters T2-WT,fractional anisotropy(FA)and mean diffusivity(MD) were acquired from the MR work station.ROIs were determined at FA and MD maps.The ten structures T2-WT values were measured in the two groups.Quantitative analyzed the the T2-WT maps and its relation to age.Results In the young group,the value of T2-WT had a left-right asymmetries in pons,cerebral peduncle,anterior internal capsual,centrum seimioval and lenticular nucleus,left>right,P=0.000~0.024.Whereas in the middle-old age group,T2-WT values were lower than the young group except the lateral cerebral ventricle,and had a left superior only in centrum semioval(P=0.042).Significant negative correlation with age were found in pons,cerebral peduncle,three parts of the internal capsule and lenticular nucleus(P=0.000~0.038).Conclusion T2-WT parameter map is more symmetry in middle-old age group.In pons,cerebral peduncle,three parts of internal capsule and lenticular nucleus,T2-WT values have significant negative correlations with age.更多还原