【摘要】 目的:通过检测梅毒血清固定患者外周血CD4~+CD25~+调节性T细胞(regulatory T ceIls,Treg)比例和功能的改变,探讨Treg在梅毒血清固定现象形成中的作用。方法:收集梅毒血清固定患者26例,正常对照23例,利用流式细胞术分别检测外周血Treg比例及Treg内Foxp3、细胞毒性T淋巴细胞抗原(CTLA)-4及白介素(IL)-10的定量表达情况。结果:梅毒血清固定组患者外周血Treg比例明显高于正常对照组(P<0.01);且Treg内转录因子Foxp3及功能性分子CTLA-4和IL-10的表达量也明显高于正常对照组(P<0.05或P<0.01)。结论:梅毒血清固定患者外周血Treg比例和功能的异常,可能是导致该现象形成的重要原因之一。更多还原

【Abstract】 Objective:To study the role of CD4~+CD25~+ regulatory T cells(Treg)in the pathogenesis of serofast syphilis. Methods:Flow cytometric analysis was employed to study the proportion of Treg in PBMC,and the quantitative expression of Foxp3,CTLA-4 and IL-10 in Treg cells of the patients with serofast syphilis.Results:Compared with the normal controls, the proportion of Treg cells,the expression of Foxp3,CTLA-4 and IL-10 in Treg cells were significant higher in the patients with serofast syphilis(P<0.05 or P<0.01).Conclusions:The abnormality of the proportion and the function of Treg cells may take part in the pathogenesis of serofast syphilis.更多还原