【摘要】 <正>耳聋是最为常见的健康问题之一,据估计全世界约有近十分之一人群有不同程度的听力下降〔1〕。2005年WHO估计双耳中到重度听力损失的有2.78亿。药物性聋是致聋的常见原因之一,3%～4%的发展中国家的成人和儿童以及相当数量发达国家的成人耳聋患者由药物(尤其氨基苷类抗生素)所致〔2〕。氨基苷类抗生素耳毒性的机制至今仍更多还原

【Abstract】 To present a summary of current knowledge regarding acute kanamycin sulfate-induced deafness in guinea pig,by reviewing the published literature.Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration.There were different time sequences of cell degeneration of spiral ganglion cell and hair cell in different studies.The findings may result from different doses,order of two drugs administration or time point chosen.There remains scope for further research in chronic kanamycin-induced deafness,which more replicates the type of exposure to people than acute deafness.更多还原