【摘要】 目的观察枯草杆菌、肠球菌二联活菌肠溶胶囊(商品名:美常安)对老年人抗生素相关性腹泻(AAD)的防治作用。方法将因感染性疾病住院、联合应用2种以上抗菌药物、治疗>5d的96例患者(年龄60～88岁)按随机数字表法分为2组,治疗组(n=49)在抗感染治疗的同时口服美常安胶囊0.5g,每天3次,直至抗感染治疗结束;对照组(n=47)仅进行抗感染治疗。观察2组AAD的发生率、治疗后肝肾功能变化。结果治疗组和对照组治疗时间分别为(12.7±7.0)、(13.6±3.2)d。治疗组和对照组AAD发生率分别为10.20%(5/49)、27.66%(13/47),2组比较差异有统计学意义(χ2=4.80,P<0.05),治疗组患者的腹泻程度较对照组也明显减轻。治疗后2组肝肾功能差异无统计学意义。结论老年人在静脉联合应用抗菌药物治疗同时口服美常安能减少AAD的发生率。更多还原

【Abstract】 Objective To observe the efficacy of live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules(Medilac-S) in the prevention and treatment of antibiotic-associated diarrhea(AAD) in elderly patients. Methods A total of 96 elderly patients aged 60-88 years who were hospitalized for infectious disease and treated with more than two kinds of antibacterial drugs for more than 7 days were randomly divided into two groups:control group(n=47) and treatment group(n=49).All patients received anti-infective therapy.The treatment group was additionally given Medilac-S 0.5 g 3 times per day until the end of anti-infective therapy.The incidence of AAD and changes in hepatic and renal function were observed in both groups.Results The treatment time was(12.7±7.0)d and(13.6±3.2)d in treatment group and control group,respectively.The incidence of AAD was 10.20%(5/49) and 27.66%(13/47) in treatment group and control group,respectively.The differences were significant between the two groups(χ2=4.80,P<0.05).Moreover,the diarrhea was obviously relieved by Medilac-S compared with control group.No significant differences in liver and kidney function were found between the two groups.Conclusion Medilac-S can reduce the incidence of AAD in elderly patients undergoing intravenous antimicrobial therapy.更多还原