【摘要】 长时间吸入高体积分数氧(高氧)可致高氧肺损伤,是导致新生儿支气管肺发育不良发生、发展的一个重要因素。高氧肺损伤的发病机制十分复杂,近年来研究表明,细胞凋亡是高氧肺损伤的一个重要组织学特点,在其发病过程中具有十分重要的作用。肺表面活性蛋白(surfactantprotein)在机体肺部防御和先天性免疫方面发挥着重要作用。目前的研究表明,肺表面活性蛋白参与多种肺部疾病的发生、发展。更多还原

【Abstract】 Inhalation of high volume fraction oxygen for long time can result in hyperoxia lung injury,which is an important factor leading to the occurrence and development of neonatal bronchopuhnonary dysplasia.The pathogenesis is very complex in hyperoxia lung injury.Several recent studies have demonstrated that apoptosis is an important histological features during high-oxygen-induced lung injury,which plays a very important role in its pathogenesis. The hydrophilic surfactant protein D(SP-D) plays an important role in host defenseand innate immunity of the lung.It has increasing evident that SP involves in the pathogenesis of many pulmonary diseases.更多还原