【摘要】 目的研究头孢丙烯分散片在中国健康人体的药代动力学。方法 10名中国健康受试者,男女各半,单剂量口服头孢丙烯分散片500 mg。用高效液相色谱法同时测定血浆中顺式和反式头孢丙烯的浓度;用DAS 2.0药代动力学程序计算药代动力学参数。结果头孢丙烯的主要药代动力学参数:Cmax为(9.62±1.29)mg.L-1,Tmax为(1.30±0.35)h,t1/2(ke)为(1.32±0.15)h,V为(34.40±5.48)L,CL为(18.16±2.96)L.h-1,AUC0-10为(27.68±4.45)mg.h.L-1,AUC0-∞为(28.22±4.70)mg.h.L-1。结论头孢丙烯在人体内符合一级吸收的一室模型。更多还原

【Abstract】 Objective To study the pharmacokinetics of cefprozil dispersible tablets in healthy volunteers.Methods Ten healthy volunteers(five males and five females) received 500 mg cefprozil dispersible tablets at a single oral dose.The concentrations of cis-cefprozil and trans-cefprozil in plasma were determined simultaneously by HPLC.The pharmacokinetic parameters were calculated by DAS program.Results After a single dose of 500 mg cefprozil dispersible tablets,the pharmacokinetic parameters for cefprozil were as follows: Cmax was(9.62±1.29) mg·L-1,Tmax was(1.30±0.35)h,t1/2(ke) was(1.32±0.15) h,V was(34.40±5.48) L,CL was(18.16±2.96) L·h-1,AUC0-10was(27.68±4.45) mg·h·L-1,AUC0-∞ was(28.22±4.70) mg·h·L-1.Conclusion Cefprozil was fitted to a one-compartment model with first absorption.更多还原