粤北地区腹膜透析患者骨矿代谢指标季节性变化特征

【摘要】 目的探讨持续性不卧床腹膜透析(CAPD)患者骨矿代谢指标的季节性变化特征。方法回顾性分析广东省粤北人民医院腹膜透析中心75例CAPD随访患者2010年10～11月、2011年1～2月、2011年4～5月、2011年7～8月4个时间点血清钙、磷、iPTH的变化趋势。结果本组患者平均年龄(53.2±16.5)岁,男/女为45/30,年轻(<64)/年长(≥65)为52/23,糖尿病/非糖尿病为32/43;血清钙夏季高(2.47±0.19mmol/L)、冬季低(2.17±0.26mmol/L),这种季节性变化在男性、年轻、非糖尿病患者更加明显;血清磷、iPTH冬季高(1.90±0.56mmol/L、399.4±384.3pmol/L)、夏季低(1.66±0.50mmol/L、261.6±325.1pmol/L),男性与女性相同,年长患者、糖尿病患者无季节性变化。结论 CAPD患者血清钙、磷、iPTH呈现季节性变化,除气温以外,广东地方特色饮食文化可能是导致这些参数变化的原因。更多还原

【Abstract】 Objective To invest the seasonal variation of bone mineral parameters among CAPD patients. Methods 75 stable CAPD patients(53.2±16.5 years;M/F: 45/30;non-DM/DM: 52/23) in our center from October 2010 to October 2011 were enrolled. Serum calcium,phosphorus,intact parathyroid hormone(iPTH) in every season in studied patients was collected. Results Serum phosphorus and iPTH reached to the highest level from Jan to Feb,then began to decrease from Apr to May and reached the lowest level from July to Aug(P<0.001,0.001,0.001,0.05 and 0.01 respectively) . In contrast,serum calcium began to increase from Apr to May and reached the highest level from July to Aug and got to the lowest level from Jan to Feb(P<0.001) . The seasonal variation in serum calcium in male,younger and non-DM patients was more apparent when compared to the female,elderly and DM patients. The seasonal variation in serum phosphorus and iPTH in male was similar to that in female,but in comparison to elderly patients and DM patients,there were apparent seasonal variation in younger patients and non-DM patients. Conclusion We demonstrated that there were seasonal variations of serum calcium,phosphorus and iPTH,especially in younger patients and non-DM CAPD patients. The weather change and life style such as dietary habit in south of China might contribute to these phenomena.更多还原