【摘要】 目的:中药可减少丙戊酸钠的用量,减轻其毒副作用,延缓脑梗死后癫痫的病情进展,并可提高脑梗死的治疗效果。方法:采用随机双盲安慰剂对照试验设计方法,选择60例癫痫患者,中医辨证证型均为癖阻脑络型患者,分为西药对照组、西药+中药组,分别服用,疗程52周。观察:①中医证侯疗效;②对患者发作次数的影响;③安全性观察。结果:①患者发作次数减少:治疗组和对照组总有效率分别为85.9%和63.1%,两组比较有统计学意义(P<0.05)。②中医证候疗效:治疗组和对照组总有效率分别为89.7%(26/29)和71.4%(20/28),两组比较有统计学意义(P<0.05)。③安全性观察:治疗组和对照组无明显不良反应。结论:活血安痫丸可以提高脑梗塞后癫痫的治疗效果,具有明显疗效和良好的安全性。更多还原

【Abstract】 Objective:TCM can reduce the using amount of sodium valproate,ease its toxic side effects,defer the progression of epilepsy after stroke,and then improve the treatment effects with cerebral infarction.Methods:Applying randomized double-blind placebo-controlled trial design method,selected 60 cases of epilepsy patients,TCM syndrome differentiation was also network-type resistance brain addiction patients,which divided into western medicine control group and western medicine plus TCM group,respectively taked,52 weeks as a course.Observation:First,syndrome effect of TCM;Second,affecting patients incidence of disease;Third,safety observation.Results:First,patients reduced incidence of disease;Treatment group and control group,the total effective rates were 85.9% and 63.1%,the two groups was statistically significant(P<0.05).Second,syndrome effect of TCM:Treatment group and control group,the total effective rate was 89.7%(26/29) and 71.4%(20/28),the two groups were statistically significant(P<0.05).Third,safety observation:Treatment and control groups weren’t significant adverse reactions.Conclusion:Huoxue Anxian wan can improve the treatment effects of epilepsy after cerebral infarction,and have significant efficacy and good safety.更多还原