【摘要】 目的:观察复方全蚕粉胶囊对2型糖尿病大鼠糖、脂代谢的影响。方法:采用高脂饲料喂养加小剂量链脲佐菌素(STZ)ip SD大鼠复制实验性2型糖尿病模型,按血糖值将模型大鼠随机分、模型组、复方全蚕粉胶囊低、中、高剂量组(0.5,1.0,2.0 g.kg-1)、阿卡波糖组(3 mg.kg-1),另设正常对照组。给药6周后测定各组大鼠空腹血糖(FPG)、血清胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血清丙二醛(MDA)、超氧化物歧化酶(SOD),并计算胰岛素抵抗指数(Home-IR)。结果:与模型组比较,复方全蚕粉胶囊各剂量组可使FPG,TC,TG,LDL-C和MDA显著降低,而HDL-C和SOD显著升高(P<0.05或P<0.01),能有效地改善高胰岛素血症状态。结论:复方全蚕粉胶囊能有效调节2型糖尿病大鼠糖、脂代谢紊乱,改善外周组织对胰岛素的敏感性,从而减轻2型糖尿病大鼠的胰岛素抵抗。更多还原

【Abstract】 Objective:To observe the influences of Compound Prescription Capsule of Silkworm Powder(CCSP) on glycometablism and lipid metabolism in type 2 diabetic rat.Method: Male Sprague-Dawley rat model of type 2 diabetes was induced by high-fat diet and low dose streptozotocin(STZ).Seventy-two model rats were separated according to plasma glucose levels into models,normal control group,model group,low dose group,middle dose group,high dose group and Acarbose tablets group.After 6 weeks,all animals were tested respectively the levels of fasting plasma glucose(FPG) and fasting insulin(FINS),cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),malonaldehyde(MDA),superoxide dismutase(SOD).Result: Compared with model group.Low,middle and high doses of CCSP could remarkably lower the levels of FPG,FINS,TG,TC,LDL-C and MDA,obviously improve the Home-IR,SOD and HDL-C(P<0.05 or P<0.01).It had the amendment of high-insulin.Conclusion: CCSP can effectively adjust the glyco-lipid metabolim,thus to abate insulin resistance.更多还原