【摘要】 目的:探讨蒲公英对小鼠肝损伤保护作用。方法:采用小鼠白酒ig制备酒精性肝损伤动物模型,成型小鼠随机分为蒲公英低、中、高治疗组(5,10,20 g·kg-1),联苯双酯治疗组(0.6 g·kg-1),模型组,各组分别给与药物治疗6周。观察用药前后各组小鼠血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)和组织匀浆中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)及一氧化氮(NO)、肿瘤坏死因子(TNF-α)水平的变化。结果:蒲公英5～20 g·kg-1可明显降低酒精性肝损伤小鼠血清中ALT,AST水平(P<0.05或P<0.01),减少肝组织匀浆的MDA,NO,TNF-α含量(P<0.05或P<0.01),升高肝匀浆SOD,GSH-Px的水平(P<0.05或P<0.01),与模型组比较,差异有统计学意义。结论:蒲公英提取物能通过改变某些炎症介质和细胞因子,从而减轻或防治相关损伤,达到抗炎的目的。更多还原

【Abstract】 Objective:To investigate the protective effect of Taraxaci Herba on alcohol-induced liver injury.Method:The paper studied alcohol-induced liver injury model in mice.The model mice were randomly divided into five groups,including Taraxaci Herba low dose group,Taraxaci Herba medium dose group,Taraxaci Herba high dose group,bifendate group and model group.Every group was respectively treated for 6 weeks with Taraxaci Herba,bifendate or normal saline accordingly.The activities of aspartate transaminase(AST),alanine transaminase(ALT) in serum,superoxide dismutase(SOD),glutathione perioxidase(GSH-Px);and the content of malondialdehyde(MDA),nitrogen monoxide(NO),TNF-α in liver were investigated.Result:Taraxaci Herba could remarkably resist the increase of ALT,AST in serum(P<0.05-P<0.01),and decrease MDA,NO,TNF-α level(P<0.05-P<0.01),and improve SOD activity and GSH-Px level(P<0.05-P<0.01),and the differences were statically significant.Conclusion:Taraxact Herba could change inflammatory mediators and cytokines significantly,thereby reducing or preventing related injury for the anti-inflammatory purpose.更多还原