【摘要】 目的:研究龙眼参黄酮对犬急性心肌缺血时心外膜电图及心肌酶的影响。方法:采用麻醉开胸犬结扎左冠状动脉前降支(LAD)制备急性心肌缺血模型,观察龙眼参黄酮对心外膜电图(EECG)和心肌酶的影响。结果:龙眼参黄酮可减少缺血程度(∑-ST),降低缺血范围(N-ST),降低血清中磷酸肌酸激酶(CPK)、乳酸脱氢酶(LDH)的活性,降低血清中游离脂肪酸(FFA)、过氧化脂质(LPO)含量,提高超氧化物歧化酶(SOD)、谷胱甘肽过氧化物(GSH-Px)、一氧化氮(NO),一氧化氮合酶(NOS)的活性。结论:龙眼参黄酮对实验性心肌缺血犬心肌具有保护作用。更多还原

【Abstract】 Objective:To investigate the effects of Longyanshen flavonoids(LF) on epicardial electrogram(EECG)and myocardial enzymes in acute myocardial ischemic dogs.Method:We adopted anesthetized thoraco-opened dogs to establish the acute myocardial ischemia models by ligation of the left anterior descending branches,the influences of LF were measured by the changes of EECG and myocardial enzymes.Result:It was observed that LF could reduce the severity and area of myocardial ischemia(∑-ST and N-ST).Moreover,LF not only decreased the content of free fatty acids(FFA) and LPO in serum,as well as the activity of CPK and lactate dehydrogenase(LDH) in serum,but also improved the activity of SOD,glutathione peroxidase(GSH-Px),nitric oxide(NO)and nitric oxide synthase(NOS).Conclusion: LF has a protective effect on myocardium in experimental myocardial ischemic dogs.更多还原