【摘要】 目的通过联合检测血清胱抑素C(CysC)与尿微量蛋白系列,探讨其在儿童过敏性紫癜(HSP)早期肾脏损害诊断中的临床价值。方法收集2009年7月至2011年1月在淮安市第二人民医院儿科住院的HSP患儿(早期尿常规阴性)46例,采用液相透射比浊法及免疫散射比浊法测定患儿CysC及尿微量蛋白系列[转铁蛋白(TRF)、N-乙酰-β-D-氨基葡萄糖苷酶/尿肌酐(NAG/UCr)、免疫球蛋白(IGGU)/UCr、白蛋白(ALBU)/UCr、α1-微球蛋白(α1MU)/UCr],同时检测尿常规和血尿素氮(BUN)、血清肌酐(SCr),并与健康对照组进行比较。结果 HSP患儿CysC、尿微量蛋白系列检测值明显高于健康对照组,差异有统计学意义(P均<0.01);46例HSP患儿血、尿6项指标联合检测异常率为80.43%(37/46);血清CysC与尿微量蛋白系列呈正相关,该检测方法有助于发现早期尿常规阴性的紫癜性肾损害。结论尿常规阴性并不能排除肾脏的早期损伤,血、尿6项指标联合检测是诊断HSP早期肾损伤的良好指标,且CysC的灵敏度及特异度均优于尿微量蛋白,故血、尿6项指标联合检测可作为临床早期诊断肾损伤的可靠依据。更多还原

【Abstract】 Objective To evaluate the value of combined detection of serum cystatin C (Cys C) and urine protein series in predicting renal damage of childhood Henoch-Schnlein purpura (HSP).Methods Serum Cys C and urine protein series were tested in 46 child HSP patients,using liquid transmission turbidity and immune nephelometry.Urine protein series included transferrin (TRF),NAG /UCr,IGGU /UCr,ALBU /UCr and α1MU/UCr.Meanwhile,serum creatinine,urine and serum urea nitrogen were determined.The results were compared with those of healthy control group.Results The value of serum Cys C and urine protein series in HSP patients were higher than those of control group (4.28±0.36) mg/L vs (0.65±0.43) mg/L for serum Cys C(P < 0.01);80.43%(37/46) HSP patients whose routine urinalysis were negative had abnormal tested value of six indexes in complete blood test and urine analysis.The value of serum Cys C had a positive correlation with urine protein series.Conclusion Six indexes in complete blood test and urine analysis including serum Cys C and urine protein series help to reveal early renal damage in HSP patients,whilst negative urinalysis can’t rule out early renal damage.The sensitivity and specificity of serum Cys C are superior to urine protein series.These six indexes are appropriate indicators in diagnosis of early renal injury in childhood HSP patients.更多还原