【摘要】 目的:分析探讨泮托拉唑联合多种抗生素在消化性溃疡患者治疗中的临床应用效果。方法:选取入住我院的消化性溃疡病例107例,随机分为两组,对照组50例(46.7%)采用奥美拉唑联合阿莫西林进行治疗,研究组57例(53.3%)应用泮托拉唑联合阿莫西林、克拉霉素进行治疗,均连续治疗5周,分析两种治疗方法的临床效果及其不良反应。结果:研究组临床总有效率、溃疡愈合率分别为93.0%(53/57)、71.9%(41/57),均显著优于对照组的84.0%(42/50)、56.0%(28/50);研究组患者Hp根除率为86.0%(49/57),显著优于对照组的64.0%(32/50),组间差异均具有统计学意义(P<0.05),而不良反应发生率则无显著性差异(P>0.05)。结论:泮托拉唑联合阿莫西林、克拉霉素对消化性溃疡的疗效显著,不良反应少,值得临床进一步推广应用。更多还原

【Abstract】 Objective:To analyze clinical effects of pantoprazole combined with antibiotics such as amoxicillin,clarithromycin in treatment of 107 cases of chronic peptic ulcer patients.Methods:107 cases of chronic peptic ulcer patients were randomly divided into two groups,50 patients(46.7%) in control group adopted prilosec combined with amoxicillin,57(53.3%) cases in experimental group were applied pantoprazole combined with amoxicillin and clarithromycin.After 5 weeks,clinical effects and side effects of the two treatment methods were recorded.Results: The total effective rate of experimental group was 93.0%(53/57),71.9%(41/57),and were significantly better than the control group 84.0%(42),56.0%(28).Eradication rates for patients with Hp in experimental group was 86.0%(49/57) significantly better than the control group 64.0%(32/50),P<0.05,however,incidence of adverse reactions were no significant difference between groups(P>0.05).Conclusions: Combination of pantoprazole and antibiotics such as amoxicillin and clarithromycin for peptic ulcer has a remarkable curative effect,and it would not increase the adventure of adverse reactions.更多还原