【摘要】 目的研究伴非酒精性脂肪肝(NAFLD)的2型糖尿病(T2DM)患者的临床特点及其与血尿酸(SUA)的关系。方法将80例住院T2DM患者分为不伴NAFLD的T2DM组(A组)和伴NAFLD的T2DM组(B组),T2DM的诊断标准符合2003年WHO标准,NAFLD诊断符合中华医学会肝脏病学会标准(2010年1月修订),高尿酸血症诊断标准参照2009年无症状高尿酸血症(HUA)合并心血管疾病诊治建议中国专家共识。收集两组的一般资料,检测糖化血红蛋白(HbA1C)、血脂、肝功能、肾功能、尿常规、游离脂肪酸(FFA)及瘦素等,进行24h尿定量分析。对两组的一般临床资料进行统计学分析。结果与T2DM组相比,伴NAFLD的T2DM组腰臀比(WHR)、SUA、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)、三酰甘油(TG)、极低密度脂蛋白胆固醇(VLDL-C)、尿微量白蛋白(UMA)均升高,FFA降低,且均有统计学意义(P<0.05)。结论合并NAFLD的T2DM患者SUA的水平显著升高。FFA及瘦素在T2DM患者SUA与NAFLD的关系中所起的作用尚不明确,仍需对大样本对象继续进行研究。更多还原

【Abstract】 Objective To understand the clinical character of the type 2 diabetes (T2DM) with nonalcoholic fatty liver (NAFLD) and its relationship with serum uric acid (SUA).Methods A total of 80 T2DM inpatients between 2008 and 2009 were selected and divided into T2DM without NAFLD group (Group A) and T2DM with NAFLD group (Group B).Their general data,including glycosylated hemoglobin A1c (HbA1C),lipid profile,liver function,renal function,leptin,free fatty acid (FFA),urine routine,24-hours urine ration were measured and analyzed.Results Compared with the patients in Group A:waist-to-hipratio(WHR),SUA,alanine aminotransferase (ALT),γ-glutamyltranspeptidase (GGT),aspartate aminotransferase (AST),triglyceride (TG) and very low density lipoprotein (VLDL) were significantly higher in Group B (P<0.05).Conclusion The level of serum uric acid in T2DM patients with NAFLD is significantly increased.The effect of FFA and leptin in the relationship between SUA and NAFLD among T2DM still need further study.更多还原