【摘要】 目的研究倍他司汀联合多奈哌齐对遗忘型轻度认知功能损害(aMCI)患者记忆减退的治疗作用。方法将aMCI患者随机分为联合治疗组和对照组,分别予倍他司汀+多奈哌齐和多奈哌齐治疗,并于治疗前、治疗第4周和第12周末时进行简明精神状态量表(MMSE)、听觉词语学习测试(AVLT)、Rey-Oriterrish复杂图形测试(CFT)评定。结果两组MMSE评分均随治疗时间延长而增高,但组内及组间比较均无差异(P>0.05);AVLT延迟回忆项(AVLT-DR)、CFT延迟回忆项(CFT-DR)评分均随治疗时间延长而增高,但治疗后联合治疗组AVLT-DR均较对照组评分高(P<0.05),而CFT-DR仅在治疗12周末时较对照组评分高(P<0.05)。结论倍他司汀能增加多奈哌齐的改善认知作用,可能与其扩张脑血管的功能有关。更多还原

【Abstract】 Objective To observe the effect of betahistine combined with donepezil on the hypomnesis of amnestic mild cognitive impairment (aMCI).Methods The participants of aMCI were exposed to betahistine + donepezil(combined treatment group)and donepezil(control group)respectively,then neuropsychologic tests such as the Mini-Mental State Examination (MMSE),Auditory Verbal Learning Test (AVLT),Complex Figure Test (CFT),were used to assess the cognitive function before the treatment and after the treatment of 4 weeks and 12 weeks.Results The scores of MMSE increased gradually with the extention of treatment,but had no marked statistically changes at all time points(P>0.05).The scores of delayed recall of AVLT (AVLT-DR)and delayed recall of CFT (CFT-DR)increased obviously(P<0.05),but compared with the control group,the scores of AVLT-DR of combined treatment group increased at both 4 weeks and 12 weeks (P<0.05),and the scores of CFT-DR increased at 12 weeks only(P<0.05).Conclusions Betahistine can increase the effect of donepezil on cognition,maybe resulting from its effect on the cerebral vascular.更多还原