【摘要】 目的探索兔深静脉血栓的建模方法。方法采用暂时阻断血流、损伤血管内皮、注入凝血酶及术后肢体固定的方法制作动物模型。于造模后48h进行彩色多普勒超声及病理检测。结果 8只兔均存活,彩色多普勒超声检查示双侧股静脉管腔均为无回声;探头加压,实验侧股静脉不能被压瘪,对照侧可被压瘪;实验侧静脉管腔内无血流及频谱信号,对照侧可见充盈管腔的血流信号及随呼吸变化的血流频谱;病理检测示实验侧股静脉可见血栓充满管腔,且与管壁无粘连,对侧股静脉没有血栓形成。结论建立了兔深静脉血栓动物模型。更多还原

【Abstract】 Objective To establish a model of deep venous thrombosis(DVT) in rabbits.Methods Animal models of venous thrombosis were made by blocking venous flow with a vascular clamp temporarily,injuring the vascular wall,and injecting thrombin in the distal vein in one side of rabbits.Then fixed the hip and knee joints of the operated sides in the flection position with plaster.48 h later,the femoral veins on both sides were examined with the ultrasonography and pathology.Results All the rabbits survived after operation.The ultrasonography showed that the femoral veins on both sides were virtually anechoic.However,the veins on the operated sides couldn’t be compressed and no flow was detected,the control sides were just the reverse.The veins on the operated side were filled with thrombus which had not adhered on the wall,but no thrombosis occurred in the control side.Conclusion A model of DVT was established in rabbits.更多还原