【摘要】 目的:探讨首发偏执型精神分裂症事件相关电位P300指标的变异情况以及与记忆功能和精神病理症状的关系。方法:对30例首发偏执型精神分裂症患者(患者组)和20例健康对照者(对照组),进行Cz(中央点)、Pz(顶叶点)电极位置的P300检测和韦氏记忆量表(WMS)测定,并应用阳性和阴性症状量表(PANSS)评定患者组的精神病理症状。结果:①患者组Cz、Pz点的P300潜伏期分别为(390.6±47.6)ms和(393.3±50.1)ms,均较对照组延长(P<0.01),波幅分别为(7.7±3.4)μV和(8.5±3.9)μV,均较对照组降低(P<0.05～0.01);②患者组记忆商数(88.1±10.0)分及短时记忆、瞬时记忆受损明显(P<0.05～0.01);③患者组Cz、Pz点的P300潜伏期与PANSS总分和各因子分呈一定程度的正相关,与WMS的记忆商数和再认、再生、触摸、背数因子分呈一定程度的负相关(P<0.05～0.01)。结论:首发偏执型精神分裂症存在记忆功能障碍,P300与WMS结合能够比较客观综合地评估疾病的认知功能。P300潜伏期的延长可能与首发偏执型精神分裂症精神病理损害和记忆功能缺损的严重程度相关。更多还原

【Abstract】 Objective: To investigate the variability of event-related potentials P300 and the relationship with memory function/psychopathology in patients with first-episode paranoid schizophrenia. Methods: Thirty patients with first-episode paranoid schizophrenia(patient group) and twenty health subjects(control group) were enrolled in the study.The auditory event-related potentials P300 at the scalp electrodes Cz,Pz and Wechsler Memory Scale(WMS) were examined in both groups,Positive And Negative Syndrome Scale(PANSS) was evaluated in patient group. Results: In comparison with control group,patients had longer latency of P300 [(390.6±47.6)ms at Cz and(393.3±50.1)ms at Pz ](P<0.01),lower amplitude of P300 [(7.7±3.4) μV at Cz and(8.5±3.9)μV at Pz ](P<0.05-0.01).The memory quotient(88.1±10.0) scores and short-term memory,immediate memory in patient group were damaged significantly(P<0.05-0.01).In patient group,the latency of P300 was correlated positively with PANSS scores and negatively with WMS scores(P<0.05-0.01). Conclusions: First-episode paranoid schizophrenia has memory deficit,which can be evaluated comprehensively by P300 and WMS.The longer latency of P300 might be associated with the increased severity of first-episode paranoid schizophrenia.更多还原