【摘要】 目的了解综合医院医务人员乙型肝炎病毒感染及乙型肝炎疫苗接种情况,为加强医务人员的防预意识提供科学的对策。方法对广州一高等医学院校综合医院医务人员年度体检时进行乙型肝炎疫苗注射情况的调查,空腹采集静脉血,用酶联免疫吸附法(ELISA)统一检测乙型肝炎五项血清学标志物;用SAS统计软件包对结果进行χ2分析。结果共调查了1554名医务人员,HBsAg阳性率6.13%;不同部门乙型肝炎疫苗接种情况不同(2χ=20.65981,P=0.008),内科接种率(39.5%)最低,外科、妇产科接种率>60.0%,传染科接种率57.8%;不同部门、不同职业自然感染产生的抗体与疫苗接种产生的抗体情况不同,传染科自然感染产生抗体率最高,为88.2%,妇科(P=0.003)、儿科(P=0.0339)以疫苗接种产生抗体率较高,分别为63.6%、58.1%;技师以自然感染产生的抗体较多,为70.6%(P=0.0181),医师则以疫苗接种产生的抗体率较高,为77.8%(P=0.000002)。结论长期从事医务工作的人员,应及早开展乙型肝炎疫苗接种等积极的保护措施,提高乙型肝炎疫苗免疫接种率;对于乙型肝炎表面抗体弱阳性者,应加强免疫接种。更多还原

【Abstract】 OBJECTIVE To learn the hepatitis B infection status and the situation of vaccine inoculation among health care workers in comprehensiveness hospital.METHODS A total of 1554 health care workers(458 males and 1096 females) in a comprehensiveness hospital in Guangzhou were surveyed on the condition of vaccine inoculation and the condition of medical service profession.The serum samples were detected hepatitis B virus marker(HBsAg,HBeAg,anti-HBs,anti-HBe and anti-HBc) by ELISA in routine annum health examination.The database and statistic analyses were performed by using SAS.RESULTS The positive rate of HBsAg was 6.13%.There is significant difference of vaccine inoculation rate in different department(P=0.008).The lowest vaccine inoculation rate was internal medicine department(39.5%).It reached to 60% in surgery,gynaecology and obstetrics department,and 57.8% in infection department.There was significant difference of antibody gained by natural infection and by vaccine inoculation in different department and different profession.The rate of antibody gained by natural infection was the highest in infection department(88.2%).The rate of antibody gained by vaccine inoculation was higher in gynaecology and obstetrics department(P=0.003),paediatric department(P=0.0339).The rate of antibody gained by natural infection was higher than that gained by vaccine inoculation in technician group(P=0.0181);while the rate of antibody gained by vaccine inoculation was higher than that gained by natural infection in doctor group(P=0.000002).CONCLUSION It has correlation with the profession character and HBV infection.The probability to get HBV infection is more in infection department and in technicians.The profession protection on medical staffs against HBV infection should strengthen.更多还原