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两面针提取物抗胃癌谱-效关系研究

Study on chromatography-efficacy relation of Zanthoxylum nitidum on gastric cancer cells

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【作者】 申庆荣黄慧学王宏虹曹利娟冯看叶月华刘华钢

【Author】 SHEN Qingrong1,HUANG Huixue2,WANG Honghong3,CAO Lijuan4,FENG Kan5,YE Yuehua4,LIU Huagang6*(1.The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China; 2.Guangxi Traditional Chinese Medical University,Nanning 530001,China; 3.Maternal and Child Health Hospital of Liuzhou,Liuzhou 545001,China; 4.Guangxi Food and Drug Administration,Nanning 530021,China; 5.Liuzhou Center for Disease Control and Prevention,Liuzhou 545007,China; 6.Guangxi Medical University,Nanning 530021,China)

【机构】 广西壮族自治区人民医院广西中医学院柳州市妇幼保健院广西壮族自治区食品药品监督管理局柳州市疾病预防控制中心广西医科大学

【摘要】 目的:探讨两面针提取物抗胃癌谱-效关系的建立方法。方法:用MTT和HPLC分别测定两面针肿瘤抑制率和指纹峰数据,再用适合的统计学方法建立谱-效关系。结果:用逐步后退法建立了两面针抗胃癌谱-效关系式。结论:该关系式具有统计学意义和实际意义,因此具有一定的参考价值。

【Abstract】 Objective: To develop a method for elucidating "chromatography-efficacy" relation of the extract of Zanthoxylum nitidum on the gastric cancer cells.Method: After obtaining the tumor inhibition rate and fingerprint peak data through MTT and HPLC,"chromatography-efficacy" relation was established by an appropriate statistical method.Result: The gastric cancer "chromatography-efficacy" relation of Z.nitidum was established by step-back technique.Conclusion: The "chromatography-efficacy" relation has statistically significant and practical significance,so it has reference value in some way.

【基金】 国家自然科学基金地区科学基金项目(30760302)
  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2011年19期
  • 【分类号】R284
  • 【被引频次】24
  • 【下载频次】611
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