【摘要】 目的了解有麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)接种史的麻疹病例的分布特点,为查找原因及提出控制措施提供基础数据。方法对浙江省2009年报告的有、无MV接种史的麻疹病例进行描述流行病学分析。结果麻疹确诊病例中,有MV接种史的比例(16.44%)明显低于非麻疹病例(41.45%)。末次接种距发病最短间隔为0d,最长为25年,中位数为3个月。接种后<1个月、1～11个月、1～9年、10～25年的发病构成分别为42.10%、30.19%、19.50%、6.92%,不同年龄组末次接种距发病时间分布不同。有MV接种史的麻疹病例与无接种史者相比部分症状较轻微,末次接种距发病6～10d的麻疹病例与其他间隔相比结膜炎比例较低。结论有MV接种史的麻疹病例可因原发性或继发性免疫失败,以及接种时已处于潜伏期后期导致发病,部分接种后6～10d发病者可能是疫苗反应。更多还原

【Abstract】 Objective To know the distribution characteristics of measles cases with vaccination history of measles attenuated live vaccine(MV)and to provide base data for Measles control and prevention.Methods A descriptive epidemiological study was conducted to analyze measles cases with or without vaccination history of measles attenuated vaccine reported in Zhejiang province in 2009.Results The confirmed measles cases with vaccination history of measles vaccine was obviously lower than(16.44%)non-measles cases(41.45%).The shortest interval between the latest MV vaccination and onset of measles case was 0d,the longest is 25 years,with a median of 3 months.The occurrence of Measles of interval proportions <1 month,1-11 months,1-9 years,10-25 years were 42.10%,30.19%,19.50%,6.92% respectively.The interval distribution was different by age groups.Some symptoms were milder in the cases with MV history than that without MV history.For cases with different interval between recent MV vaccination and onset of measles,conjunctivitis was less in those of 6-10d than others.Conclusion Measles cases with MV history could be resulted from primary or secondary immunization failure,or time vaccinated at the late incubation period.Few cases may actually be vaccine reactions at 6-10d after vaccination.更多还原