【摘要】 目的:探讨有家族遗传史多囊卵巢综合征(PCOS)患者糖代谢及胰岛素抵抗(IR)的特征。方法:将确诊的PCOS患者分为有家族史及无家族史两组各30例,检测其生殖激素、葡萄糖耐量(OGTT)并行胰岛素释放试验。结果:①有无家族史PCOS患者两组间生殖激素各项指标差异无统计学意义。②OGTT及空腹胰岛素(INS)两组间差异无统计学意义,餐后1、2 h INS两组间差异有统计学意义,家族史组明显高于无家族史组。③INS敏感性指数及IR的稳态模型两组间差异无统计学意义。结论:有家族史PCOS患者的高INS血症的状态比无家族史者更为严重,符合动态突变引起的遗传不稳定性疾病所特有的一代比一代重的临床特征。更多还原

【Abstract】 Objective:To explore the characteristics of glucose metabolism and insulin resistance of patients suffering from polycystic ovary syndrome(PCOS) with family history.Methods:The patients who were diagnosed as PCOS definitely were divided into family history group and non-family history group,30 patients in each group,their reproductive hormones levels were detected,oral glucose tolerance test(OGTT) and insulin release test(IRT) were conducted.Results:①There was no significant difference in the levels of reproductive hormones between the two groups.②There was no significant difference in OGTT and fasting insulin level between the two groups,but there was significant difference in one-hour postprandial insulin level and two-hour postprandial insulin level between the two groups,the levels in family history group were significantly higher than those in non-family history group.③There was no significant difference in insulin sensitivity index and steady-state model of insulin resistance between the two groups.Conclusion:The state of hyperinsulinemia in patients with family history is worse than that in patients without family history,which conforms to the characteristics of instable hereditary diseases induced by dynamic mutation.更多还原