【摘要】 目的:探讨肺泡表面活性物质(珂立苏)联合鼻塞式持续气道正压通气(NCPAP)治疗重症胎粪吸入综合征的临床疗效。方法:将58例胎粪吸入综合征患儿随机分成两组。治疗组28例,采用NCPAP及常规治疗的同时气道注入珂立苏;观察组30例,给予NCPAP及常规治疗。观察两组患儿血气数值、氧合功能,NCPAP参数和临床疗效。结果:治疗后的不同时期,治疗组患儿的PO2和氧合指数明显高于对照组,PCO2明显低于对照组,差异有统计学意义;治疗组NCPAP参数PEEP和FiO2能及早下调,上机时间、用氧时间及改机械通气病例数均显著少于对照组。结论:珂立苏联合NCPAP治疗重症胎粪吸入综合征疗效显著、方法简单、安全性好,值得临床推广应用。更多还原

【Abstract】 Objective:To explore the clinical efficacy of pulmonary surfactant(PS) combined with nasal continuous positive airway pressure(NCPAP) in treatment of severe meconium aspiration syndrome(MAS).Methods:58 children with MAS were divided into two groups randomly:28 children in treatment group were treated with NCPAP,conventional treatment and airway application of PS;30 children in observation group were treated with NCPAP and conventional treatment.The indexes of the blood gas,oxygenation functions,NCPAP parameters and clinical efficacies in the two groups were observed.Results:At different periods after treatment,PO2 and oxygenation index in treatment group were significantly higher than those in control group,while PCO2 in treatment group were significantly lower than that in control group;NCPAP parameters(PEEP and FiO2) in treatment group could fall timely;the time of mechanical ventilation,oxygen time and the number of cases converting to mechanical ventilation in treatment group were significantly lower than those in control group.Conclusion:The clinical efficacy of PS combined with NCAPA is quite effective,simple and safe in treatment of severe MAS,which is worthy to be popularized.更多还原