【摘要】 目的:建立高效液相法测定奥美拉唑镁肠溶片含量的方法。方法:采用Diamonsil-C18(4.6 mm×150 mm,5μm)色谱柱;流动相:甲醇-水-磷酸-三乙胺(65∶35∶0.12∶0.3);检测波长:302 nm;流速:1.0 ml/min。结果:奥美拉唑镁在13.3182～31.0758μg范围内与峰面积呈良好的线性关系(r=0.999 0),平均回收率为101.14%,RSD=1.64%。结论:本法简便、准确、重现性好,可用于奥美拉唑镁肠溶片的质量控制。更多还原

【Abstract】 Objective: To establish a method for the content determination of Omeprazole Magnesium in Omeprazole Magnesium Enteric-coated Tablets by HPLC.Methods: The Diamonsil-C18(4.6 mm×150 mm,5 μm) column was used.The mobile phases consisted of methanol,water,phosphoric acid and triethylamine(65∶35∶0.12∶0.3),the flow rate was 1.0 ml/min and the detection wavelength was at 302 nm.Results: The linear ranges of Omeprazole was at 13.318 2-31.075 8 μg(r=0.999 0),the average recovery was 101.14% with a RSD of 1.64%.Conclusion: The method is fast,reliable,accurate and can be used in the quality control of Omeprazole Magnesium in Omeprazole Magnesium Enteric-coared Tablets.更多还原