【摘要】 幽门螺杆菌(HP)是引起人类胃肠疾病最常见的致病菌之一,其致病机制非常复杂,既涉及细菌因素,也涉及宿主因素。近年来,随着免疫学、生物技术的发展,越来越多的研究发现HP感染宿主后与胃黏膜上皮接触及定植,机体会产生较复杂的炎性免疫反应。但机体免疫反应并不能有效地清除细菌,且随感染持续而致病。机体胃肠道免疫系统在防御HP感染过程中起重要作用。现就HP感染与胃肠道免疫在黏膜组织、细胞及分子水平的免疫反应及调节予以综述。更多还原

【Abstract】 Helicobacter pylori(HP)is the main pathogenic bacteria that cause gastrointestinal diseases.The pathogenic mechanism is very complex,including bacterial and host factors.In recent years,with the development of immunology and biotechnology,more and more studies show that HP infects and colonizes host gastric mucosa epithelial cells,whereas the host produces very complex inflammatory and immune responses.However,the immune response of the host cannot effectively eliminate the bacteria,allowing the continuous infection and the onset of gastrointestinal diseases.The immune system of the gastrointestinal tract plays an important role in defending HP infection.This article mainly reviews the immune response and regulation of HP infection and gastrointestinal mucosal immunity at the levels of tissue,cell and molecule更多还原