【摘要】 目的探讨血清新蝶呤水平与传染性单核细胞增多症的关系。方法采用酶联免疫吸附试验(ELISA)检测80例传染性单核细胞增多症患儿及60例健康儿童的血清新蝶呤水平。结果传染性单核细胞增多症患儿组血清新蝶呤水平明显高于健康对照组(P<0.05),治疗后临床症状明显缓解的传染性单核细胞增多症患儿,其血清新蝶呤水平较治疗前明显下降(P<0.05)。结论传染性单核细胞增多症患儿新蝶呤水平升高,提示免疫激活参与了传染性单核细胞增多症的病理生理过程,动态检测血清新蝶呤,对疾病的诊断及疗效监测有一定的临床价值。更多还原

【Abstract】 Objective To investigate the relationship between serum neopterin levels and infectious mononucleosis.Methods The study population comprised 80 children with infectious mononucleosis and 60 normal controls.Serum neopterin levels were measured by the method of enzyme-linked immunosorbent assay.Results Serum neopterin levels in children with infectious mononucleosis were significantly higher than the control group(P<0.05).Serum neopterin levels in children with infectious mononucleosis were dropped after therapy(P<0.05).Conclusion Serum neopterin levels strongly increased in children with infectious mononucleosis.Serum neopterin levels can be considered as a marker of cellular immune activity in children with infectious mononucleosis.Dynamic measurement of serum neopterin may help to diagnosis and evaluation of therapy effect.更多还原