节点文献

复方首乌软胶囊对D-半乳糖致亚急性衰老小鼠p16基因表达的影响

Effects of Shouwu Soft Capsules on p16 Gene Expression of D-Galactose-induced Subacute Aging Mice

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 姚毅谭喜莹王淑云朱萱萱

【Author】 YAO Yi,TAN Xi-ying,WANG Shu-yun,ZHU Xuan-xuan Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,China

【机构】 江苏省中医院

【摘要】 目的:研究复方首乌软胶囊对衰老小鼠p16基因表达的影响,探讨复方首乌软胶囊的抗衰老机制。方法:用D-半乳糖建立衰老小鼠模型,以复方首乌软胶囊治疗,实时荧光定量PCR法观察小鼠脑海马p16基因的mRNA表达。结果:复方首乌软胶囊组p16基因mRNA表达降低。结论:复方首乌软胶囊能降低p16基因的表达,从而起到抗衰老作用。

【Abstract】 Objective: To study the effects of Shouwu Soft Capsules on p16 gene expression in D-galactose-induced subacute aging mice.Methods: The mice was injected with D-galactose to built the model of aging and then treated with Shouwu Soft Capsules,the mRNA expression of p16 gene in brain was observed.Results: mRNA expression of p16 gene in Shouwu Soft Capsules groups was decreased.Conclusion: Shouwu Soft Capsules can decrease the expression of p16 gene and have antiaging actions.

【基金】 江苏省中医药管理局基金项目(K2009J045-p)
  • 【文献出处】 药学与临床研究 ,Pharmaceutical and Clinical Research , 编辑部邮箱 ,2011年05期
  • 【分类号】R285.5
  • 【被引频次】2
  • 【下载频次】95
节点文献中: