【摘要】 目的分析2型糖尿病患者糖化血红蛋白(HbA1c)与甲状腺激素水平的相关性,探讨长期血糖控制对糖尿病甲状腺功能影响的临床意义。方法采用化学发光法检测2型糖尿病及健康对照组游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺素(S-TSH),使用高效液相色谱仪分析HbA1c,同时分析受试者空腹血糖(FBG)。结果 2型糖尿病组FT3低于正常对照组(P<0.01),S-TSH高于对照组(P<0.01),FT4低于对照组,但差异无显著性(P>0.05);2型糖尿病患者FBG与HbA1c量成正相关(P<0.01),HbA1c与FT3浓度成负相关(P<0.05)。结论 2型糖尿病患者甲状腺激素水平紊乱增多且与长期高血糖相关。更多还原

【Abstract】 Objective To investigate the effects of long-term control of blood sugar in patients with type 2 diabetes mellitus by analyzing the correlation of the levels of glycosylated hemoglobinA1c(HbA1c) and thyroid hormone.Methods A chemiluminescence method was used to determine the serum concentrations of FT3,FT4 and S-TSH in patients with type 2 diabetes mellitus and in healthy control group.Meanwhile a High Performance Liquid Chromatography(HPLC) was used to analyze the glycosylated hemoglobinA1c(HbA1c) and the fasting blood glucose(FBG) in patients with type 2 diabetes mellitus(type 2 diabetes mellitus group) and in healthy control group.Results In the type 2 diabetes mellitus group,FT3 lowered,there was statistically significant difference(P<0.01),compared to the control group,S-TSH was higher than those in the control group (P<0.01),and the FT4 was lower,but there was no statistical difference,conpared to those in the control group(P>0.05).In patients with type 2 diabetes mellitus,FBG is positively associated with the concentrations of HbA1c(P<0.01),and is negatively associated with FT3(P<0.05).Conclusion The serun levels of thyroid horme disorder improves and is related to long-term high blood sugar in patients with type 2 diabetes mellitus.更多还原