【摘要】 目的:研究水飞蓟宾—磷脂酰胆碱复合物（silybin-phosphatidylcholine compound,SPC）对D—半乳糖胺（D-galactosamine,D-galN）和脂多糖（1ipopolysaccharide,LPS）与卡介苗（Bacillus Calmette-GuerinVaccine,BCG）诱导的小鼠肝损伤实验的影响。方法:将100只小鼠随机分成10组,分别用于SPC对D-galN和LPS+BCG诱导的小鼠肝损伤影响实验。分别用D-galN和LPS+BCG复制肝损伤动物模型,测定血清中ALT、AST和肝组织中TG水平并进行肝脏病理组织学检查。用200mg·Kg^-1SPC剂量对2种肝损伤小鼠进行处理,观察SPC对血清酶学及组织学改变的影响。结果:SPC不同程度的使D-galN和LPS+BCG诱导升高的ALT、AST和TG明显降低（p<0.05）,并能减轻两种肝损伤动物模型肝脏组织学结构的改变。结论:SPC对D-galN和LPS+BCG诱导的肝损伤具有明显的保护作用。更多还原

【Abstract】 Objective:To investigate the effectiveness of silybin-phosphatidycholine compound（SPC） on liver injury of mice induced by D-galactosamine（D-galN） and bacilli calmette-guerin（BCG）+lipopolysaccharide （LPS）.Methods:100 mice were randomly divided into 10 groups and used separately for studying the effectiveness of SPC on liver injury of mice induced by D-galN and BCG+LPS.The activities of ALT,AST and TG were measured in the serum in mice and the liver histopathologic changes examined with microscope as evaluation index of injury degree and protecting efficacy.After treated with 200mg·Kg^-1 SPC in the two types of injuried mice,sero-enzyme activity and histopathologic alteration were examined.Results SPC could inhibit the increasing activities of AST,ALT and TG induced by D-galN as well as LPS+BCG（p<0.05）,and also lessened the histology alteration of liver injury model.Conclusion:SPC can obviously inhibit the liver injury induced by D-galN as well as LPS+BCG.更多还原