【摘要】 为检测CCNG2在胃癌中的表达改变,并探讨其变化与胃癌临床参数和预后之间的关系,构建了225例胃癌组织芯片。用免疫组化检测了CCNG2的表达,分析其表达与临床病理参数及胃癌患者预后的关系。免疫组化结果显示,CCNG2在癌旁粘膜中均有表达,而胃癌中的表达率为51.1%(115/225)。CCNG2的表达与肿瘤浸润深度、淋巴结转移、疾病分期以及组织学分化呈负相关。生存分析表明,CCNG2可以是判断胃癌患者预后的独立指标。由此得出结论,CCNG2在胃癌的发生发展过程中起着重要作用,可作为判断胃癌患者预后的指标。更多还原

【Abstract】 In order to investigate CCNG2 expression and determine its clinical significance in gastric carcinoma, tissue microarray blocks containing tumor specimens from 225 patients were constructed.Expression of CCNG2 in these specimens was analyzed using immunohistochemical detection.The expression of CCNG2 was observed in 115 cases(55.1%) of 225 primary tumors.CCNG2 expression was significantly inversely associated with advanced T stages,lymph node metastases,advanced disease stage,and poor histological differentiation.Loss of CCNG2 expression significantly correlated with poor survival both in univariate and multivariate analyses.Our results showed that CCNG2 could be involved in the development and progression of gastric cancer.CCNG2 expression could be as a biomarker for progression of gastric cancer.更多还原