【摘要】 目的比较初诊2型糖尿病(T2DM)患者服用消渴丸、瑞格列奈治疗前后空腹、30、120 min真胰岛素量及其与放免胰岛素比值的变化特征。方法初诊T2DM患者90例,随机分为消渴丸组44例,瑞格列奈组46例。留取治疗前后空腹、30 min和120 min静脉血,采用葡萄糖氧化酶法测定血糖,酶联免疫吸附法测定真胰岛素(TI),放射免疫法测定放射免疫性胰岛素(IRI),并计算各时刻TI/IRI。结果消渴丸组治疗后,30 min时TI/IRI较治疗前有所增加,但差异无统计学意义(P>0.05),高峰在120 min时,TI/IRI与治疗前相比有明显增加(0.60±0.13 vs 0.53±0.14,P<0.05);瑞格列奈组治疗后,TI/IRI的高峰在30 min时与治疗前相比有明显增加(0.63±0.08 vs 0.44±0.17,P<0.05)。结论初诊T2DM患者经消渴丸治疗后,可显著改善120 min时胰岛素分泌的质与量,与瑞格列奈组治疗后早期相胰岛素分泌的质与量存在一定的差异。更多还原

【Abstract】 Objective To observe characteristic changes of true insulin secretion and ratios of true insulin to immunoreactive insulin(TI/IRI) in patients newly diagnosed as having type 2 diabetes mellitus(T2DM) before and after treatment with xiaoke pills or repaglinide.Methods 90 patients with newly diagnosed T2DM were randomly divided into two groups: 44 patients in the xiaoke pills group,and 46 patients in the repaglinide group.After collecting fasting,30 min and 120 min venous blood before and after treatment,blood glucose was measured with the glucose oxidase method,true insulin with ELISA and immunoreactive insulin with radioimmunoassay.TI/IRI was calculated at various times.Results 120 min TI/IRI in xiaoke pills group had an obvious increase after treatment compared with that before treatment[(0.60±0.13) vs(0.53±0.14),P<0.05],while 30 min TI/IRI had a minor increase(P>0.05).30min TI/IRI in the repaginate group had an obvious increase compared with that before treatment[(0.63±0.08) vs(0.44±0.17),P<0.05].Conclusions The quality and quantity of true insulin secretion in 120 minutes have obvious improvement after treatment with xiaoke pills.The quality and quantity of true insulin secretion in 30 minutes have an obvious difference compared with treatment with repaglinide.更多还原