【摘要】 目的:观察中药甘遂在治疗重症急性胰腺炎(SAP)中的疗效,探讨其作用机制以及应用甘遂治疗SAP的中医学理论根据。方法:将43例患者随机分为2组,对照组予常规治疗方案,甘遂组在对照组治疗的基础上加用甘遂治疗,观察2组临床症状、实验室指标。结果:腹痛缓解时间,肠鸣音、血淀粉酶、尿淀粉酶、血白细胞计数恢复时间甘遂组与对照组比较,差异均有非常显著性意义(P<0.01);治疗第7天2组血清肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)浓度分别比较,差异均有非常显著性意义(P<0.01);2组急性呼吸窘迫综合征、胰腺及胰周脓肿、胰腺假性囊肿发生率比较,差异有显著性或非常显著性意义(P<0.05,P<0.01),2组休克、肾功能衰竭、胰性脑病发生率比较,差异均无显著性意义(P>0.05)。结论:应用甘遂治疗SAP有确切疗效。更多还原

【Abstract】 Objective:To observe the effect of Radix Kansui(RK)in treating severe acute pancreatitis(SAP).Methods: Forty-three cases of SAP were randomly divided into the control group and the treatment group.The two groups received routine treatment,and the treatment group received RK additionally.The clinical symptoms and laboratory parameters were determined and compared between two groups.Results:The time for abdominal pain relief,and time for bowel sound,hemodiastase, urinary amylase and white blood cell count becoming normal in the treatment group differed from those in the control group(P<0.01).On the seventh day of treatment,the serum levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6) in the treatment group were significantly lower than those in the control group(P<0.01).Incidences of acute respiratory distress syndrome,pancreatic and parapancreatic abscess,and pancreatic pseudocyst was significantly lower in the treatment group than those in the control group(P<0.05).Conclusion:Radix Kansui is effective for the treatment of severe acute pancreatitis.更多还原