【摘要】 目的探讨精子顶体酶活性与体外受精的关系。方法将236个体外受精-胚胎移植(IVF-ET)治疗周期根据顶体酶活性分成三组:A组≥48.2μIU/106精子,共95周期;B组:30～48.1μIU/106精子,共92周期;C组<30μIU/106精子,共49周期;比较三组间的受精率、卵裂率、优质胚胎率。结果 A、B、C组的受精率分别为77.02%、74.11%和48.69%,卵裂率分别为97.80%、96.65%和90.29%,优质胚胎率分别为41.32%、40.79%和33.42%。三组间卵裂率、优质胚胎率比较,差异无统计学意义(P>0.05)。C组的受精率明显低于A组(P<0.05),且完全不受精的发生率高于A、B组(P<0.05)。B组与C组相比受精率下降,但差异无统计学意义(P>0.05)。结论当顶体酶活性低于30μIU/106精子时受精率显著下降,可考虑行部分卵胞浆内单精子注射治疗。更多还原

【Abstract】 Objective To study the relationship between sperm acrosin activity and IVF.Method Based on the level of sperm acrosin activity,236 cases of IVF-ET were divided into three groups.Group A:≥48.2 μIU /106 sperm,total 95 cycles;Group B:30～48.1 μIU /106 sperm,total 92 cycles;Group C:﹤30 μIU /106 sperm,total 49 cycles.The rates of fertilization,cleavage and good embryos of the three groups were compared.Results There was no statistical differences between A,B and C groups in the rates of cleavage and good embryos(P>0.05).The rate of fertilization in group C was significantly lower than in group A(P<0.05),but not significantly different from B group even though the data showed that the rate was lower in group B.Conclusion When the sperm acrosin activity was lower than 30 μIU/106,the rate of fertilization was obvious decreased.Then intracytoplasmic sperm injection treatment may be helpful.更多还原