【摘要】 目的观察来得时(甘精胰岛素)与那格列奈联合应用治疗门诊2型糖尿病的临床疗效。方法选择符合诊断标准的2型糖尿病患者68例,给予睡前注射来得时并三餐前口服那格列奈,观察12周,分别检测治疗前、后空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)。结果治疗后1、2、4、8、12周的FBG、PBG、HbA1c均较治疗前显著降低(P<0.05),低血糖的发生率低。结论来得时联合应用那格列奈可更好的模拟生理性胰岛素分泌,有效降低血糖,不良反应少,病人依从性好。更多还原

【Abstract】 Objective To observe the clinical efficacy of Lantus(insulin glargine)combinaed with nateginide on type 2 diabetes cases.Methods Sixty-eight type 2 diabetes cases meeting the diagnostic criteria of type 2 diabetes were injected with Lantus bedtime and administrated nateginide orally before 3 meals and observed for 12 weeks..The levels of fasting blood sugar(FBG),glycated hemoglobin(HBALC)and Postprandial Blood Glucose(PBG)were measured before and after treatment,2 hours after treatment.Results 1,2,4,8,12 weeks after treatment,the FBG,PBG,HbA1c were significantly lower than that before treatment(P<0.05)with a low incidence of hypoglycemia.Conclusion The effect of combination of Lantus and nateginide can better simulate the physiological insulin secretion and reduce blood sugar.And the adverse reactions were mild and the patient compliance was good.更多还原