【摘要】 目的了解河南省肿瘤医院肿瘤患者血培养的病原菌分布和耐药情况,为临床合理用药提供依据。方法对2006年1月～2009年10月送检的血液或骨髓标本按常规方法进行细菌分离、菌种鉴定和药敏试验,对结果作统计分析。结果 4年血培养中革兰阴性菌,检出率依序分别为53.8%、46.9%、40.0%、53.3%,连续4年保持在第一位;革兰阳性菌检出率分别为26.4%、35.0%、30.0%、23.7%,(除外2008年)保持在第二位;真菌检出率分别为19.8%、18.1%、30.0%、23.0%。检出最常见的菌种依次是:大肠埃希菌、凝固酶阴性葡萄球菌(CNS)、金黄色葡萄球菌、肺炎克雷伯菌、皱褶念珠菌、近平滑念珠菌。连续4年大肠埃希菌及肺炎克雷伯菌对亚胺培南、美罗培南敏感率达100%;凝固酶阴性葡萄球菌及金黄色葡萄球菌对万古霉素和替考拉宁敏感率达100%,均未发现耐药株。结论 2006～2009年我院肿瘤患者血液感染以革兰阴性菌尤其以大肠埃希菌为主,且具有多重耐药性,血培养分离菌中真菌也占一定比例。因此,及时监测感染病原菌谱变化及耐药趋势,对指导临床用药至关重要。更多还原

【Abstract】 Aim To analyze the distribution and the drug resistance of pathogenic bacteria in blood culture of tumor patients.Methods The blood or the bone marrow samples collected from tumor patients during January 2006 to October 2009 were cultured by conventional methods and the pathogens were identified and drug susceptibility tests were conducted.Results The positive rates of gram-negative bacteria were 53.8%,46.9%,40.0% and 53.3% ranked on the top in last 4 years;the positive rates of gram-positive bacteria were 26.4%,35.0%,30.0% ang 23.7%;the positive rates of fungi were 19.8%,18.1%,30.0% ang 23.0%.The common bacteria detected were the following order:Escherichia coli,coagulase-negative staphylococci(CNS),Staphylococcus aureus,Klebsiella pneumoniae,fold Candida and Candida parapsilosis.The susceptibility of Escherichia coli and Klebsiella strains to imipenem and meropenem were 100%,that of Coagulase-negative Staphylococci and Staphylococcus aureus to vancomycin and teicoplanin were 100%.Conclusion Most of the tumor patients were infected with Gram-negative bacteria and Escherichia coli predominated with multiple drug resistance.更多还原