【摘要】 目的分析高尿酸血症(HUA)患者抵抗素水平及其相关影响因素。方法测定208例HUA患者(HUA组)及200例血尿酸正常者(NUA组)的空腹血清抵抗素水平及其他生化指标,进行组间比较,并分析影响抵抗素水平的相关因素。结果 HUA组的收缩压(SBP)、体质指数(BMI)、腰围(WC)、空腹胰岛素(FINS)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、胰岛素抵抗指数(HOMA-IR)及抵抗素水平高于NUA组,差异均有统计学意义(P<0.05);两组服糖后2 h血糖(2 hPG)、舒张压(DBP)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)水平间差异均无统计学意义(P>0.05)。在HUA组,以抵抗素为因变量,以年龄、SBP、DBP、BMI、WC、FPG、FINS、2 hPG、HDL-C、LDL-C、TC、TG和HOMA-IR为自变量进行Logistic回归分析显示,HUA患者抵抗素水平升高的危险因素为BMI、WC、FINS、FPG和TG。结论 HUA患者的抵抗素水平显著高于尿酸正常者,抵抗素水平主要与FPG、FINS、TG、BMI及WC有关。更多还原

【Abstract】 Objective To analyze serum resistin levels and the correlated factors in patients with hyperuricacidemia.Methods Fasting serum levels of resistin,together with some other biochemical indices,were examined in 208 hyperuricacidemia(HUA) patients and 200 normouricemia(NUA) controls.Comparison between the two groups were carried out with the correlated factors of resistin levels analyzed.Results Systolic pressure,body mass index(BMI),waist circumference(WC),levels of fasting serum insulin(FINS),triacylglycerol(TG),and low density lipoprotein cholesterol,insulin resistance index,and fasting serum resistin levels were significantly higher in the HUA group than in the NAU group(P<0.05).Postprandial blood sugar levels,diastolic pressure,levels of high density lipoprotein cholesterol and total cholesterol were not significantly different between the two groups(P>0.05).Logistic regression analysis demonstrated that fasting plasma glucose(FPG),FINS,TG,BMI and WC were risk factors for fasting resistin level.Conclusion Fasting serum resistin levels are higher in the HUA population than in their NUA counterparts.Fasting resistin level is strongly correlated with FPG,FINS,TG,BMI and WC.更多还原