【摘要】 目的研究羊栖菜多糖(SFPS)对体外培养的人肺癌细胞SPC-A-1、血管内皮细胞及肿瘤血管内皮细胞模型增殖活性的影响。方法采用四甲基偶氮唑盐(MTT)观检测羊栖菜多糖对人肺癌细胞SPC-A-1、血管内皮细胞及肿瘤血管内皮细胞模型的增殖活性的影响。结果 300及1000 mg/L浓度SFPS可明显抑制SPC-A-1细胞的增殖活性;30及100 mg/L浓度SFPS对人胎儿脐静脉内皮细胞的增殖具有促进作用,但明显抑制SPC-A-1诱导的肿瘤血管内皮细胞模型的增殖活性。结论高浓度SFPS可抑制人肺癌细胞SPC-A-1增殖活性,并可通过抑制肿瘤血管内皮细胞的增殖而抑制肿瘤的生长。更多还原

【Abstract】 Objective To study the effect of Sargassum fusiforme polysaccharides(SFPS)on the proliferation of lung cancer cells,such as SPC-A-1 and human umbilical vein endothelial cells(HUVECs),and tumor vascular en-dothelial cells.Methods Proliferate activity of SPC-A-1、HUVECs and tumor vascular endothelial cells was moni-tored by MTT assay.Results SFPS at 300 mg/L、1 000 mg/L concentration significantly reduced proliferation of SPC-A-1.SFPS at 300 mg/L、1 000 mg/L concentration increased proliferate activity of HUVECs,but the prolifera-tion of tumor vascular endothelial cells was obviously restrained in SFPS groups(300 mg/L、1 000 mg/L.) Con-clusions SFPS at high concentration can reduce proliferate activity of SPC-A-1,and SFPS can also restrain the gro-wth of tumor by means of reducing the proliferation of tumor vascular endothelial cells.更多还原