【摘要】 目的了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清白介素10(IL-10)、一氧化氮(NO)及C反应蛋白(CRP)水平的变化,探讨OSAHS的发病机制。方法选取男性35例经多导睡眠图监测确诊的重度OSAHS患者为实验组,25例年龄、体重指数等均相匹配的健康查体者为对照组,用ELISA检测血清中IL-10、NO及CRP的水平。结果 OSAHS组NO及CRP水平显著高于健康对照组(P<0.01),而IL-10水平低于健康对照组(P<0.05)。结论反复的夜间低氧可使炎性因子升高,降低抑炎因子水平。更多还原

【Abstract】 Objective To investigate the levels of the interleukin 10,NO and CRP in patients with obstructive sleep apnea-hypopnea syndrome.Methods thirty-five severe OSAHS male patients underwent uvulopalatopharyngoplasty were selected as OSAHS group and matched for age,BMI to twenty-five health persons as control group.Serum levels of IL-10,NO and CRP were measured by ELISA.Results The level of CRP was significantly higher than those in control but IL-10 and NO were significantly lower.Conclusion The levels of IL-10,CRP and NO might be related with hypoxemia occurred repeatedly during night.更多还原