【摘要】 目的探讨不同疗程泮托拉唑、克拉霉素、阿莫西林克拉维酸钾三联根除幽门螺杆菌(Hp)的疗效,寻找合理的治疗疗程。方法将150例Hp阳性患者随机分为7、10、14日治疗3组,分析Hp根除率、症状缓解率和不良反应发生率。结果 10日组和14日组的Hp根除率均显著高于7日组(89.6%9、1.3%vs 73.4%,P<0.05),而10日组与14日组两组之间差异无统计学意义(P>0.05);各组症状缓解率比较差异无统计学意义(P>0.05);7日组和10日组的不良反应发生率均明显低于14日组(4.1%6、.2%vs 21.7%,P<0.05),而10日组与14日组两组之间差异无统计学意义(P>0.05)。结论 10日疗法可考虑作为本地区根除Hp、治疗Hp感染的慢性胃炎和消化性溃疡较为理想的方案。更多还原

【Abstract】 Objective To study the efficacy of different course therapy of pantoprazole,clarithromycin and amoxicillin and clavulanate potassium granules combined for Helicobacter pylori((Hp) eradication and to finding the reasonable therapy.Methods Hp infection 150 patients into three groups,including 7 days(7 d group),10 days(10 d groups) and 14 days(14 d group).The randomly divided eradication rates of Hp,the rate of relieves of symptoms,the incidence rate of adverse effect were analyzed.Results The eradication rates of Hp was statistical different between 10 d group 14 d group and 7 d group(89.6%,91.3% vs 73.4%,P<0.05),there was no statistical difference between 10 d group and 14 d group(P>0.05).The rate of relieves of symptoms was no statistical difference between different groups(P>0.05).The rates of adverse effect in 7 d group and 10 d group were lower than 14 d group(4.1%,6.2% vs 21.7%,P<0.05),but there was no statistical difference between 10 d group and 7 d group(P>0.05).Conclusion The best choice was the 10 d therapy for eradicating Hp and treating the Hp infection of peptic ulcer and gastritis.更多还原