【摘要】 目的高危型人乳头瘤病毒(human papillomavirus,HPV)感染是宫颈癌的主要致病原因,现已发现HPV感染可诱发人类的许多恶性肿瘤。文中旨在探讨高危型HPV在结直肠肿瘤(colorectal tumor,CRT)中的感染情况以及与HPV感染的关系。方法从203例结直肠肿瘤石蜡组织标本中提取16、18型HPV的基因,其中结直肠绒毛-管状腺瘤(colorectal villus-tubiform adenoma,CRVTAN)83例、结直肠腺癌(colorectal adenocarcinoma,CRAC)120例,采用聚合酶链反应进行基因扩增检测,并对其患者进行临床病理资料分析。结果 83例CRVTAN总的HPV感染率为57.83%(48/83)、120例CRAC总的HPV感染率为75.00%(90/120),且与HPV感染密切相关(r分别为23.4、47.3,P<0.01)。结论结直肠肿瘤与HPV感染有着密切的关系,无论腺瘤、还是腺癌,直肠及乙状结肠都是结直肠HPV的高感染部位,这合理的解释了长期以来直肠、乙状结肠腺癌在CRAC中的高发病率现象。更多还原

【Abstract】 Objective High-risk human papillomavirus(HPV) infection is the major cause of cervical cancer,and it has proved that HPV infection may induce various malignant tumors in human.We studied HPV infection among colorectal tumor patients and the relationship of colorectal tumors with HPV infection.Methods Types 16 and 18 HPV were obtained from the paraffin specimens of 203 cases of colorectal tumor,including 83 cases of colorectal villus-tubiform adenoma(CRVTAN) and 120 cases of colorectal adenocarcinoma(CRAC).Gene amplification was performed by PCR,and the clinicopathologic data of the patients were analyzed.Results The HPV infection rates were 57.83%(48/83) and 75.00%(90/120) in the CRVTAN and CRAC patients,respectively(r = 23.4 and 47.3,P<0.01).Conclusion HPV infection is closely related with colorectal tumor,either adenoma or adenocarcinoma.The rectum and sigmoid colon are the locations of high-risk HPV infection,which explains the high incidence of adenocarcinoma in the rectum and sigmoid colon.更多还原