【摘要】 目的探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病的关系及其与疾病临床表现严重程度的关系。方法酶联免疫吸附法检测90例脑梗死患者,44例短暂性脑缺血发作(TIA)患者和40例同期门诊体检者(对照组)血浆Hcy水平并记录脑血管病患者的传统危险因素;对脑梗死组患者进行神经系统功能缺损评分(NIHSS)。分析血浆Hcy与缺血性脑血管病的关系及其与缺血性脑血管病的部分类型以及病情严重程度的相关性。结果缺血性脑血管病组、脑梗死组与TIA组患者血浆Hcy水平均高于对照组(P<0.05),脑梗死与TIA患者血浆Hcy水平相比较差异无统计学意义(P>0.05);血浆Hcy水平与NIHSS评分无明显相关性(r=0.155,P=0.323);采用多因素Logistic回归分析,血浆Hcy进入模型。结论血浆Hcy水平升高可能是与传统危险因素无关的缺血性脑血管病的独立危险因素,但Hcy水平与其类型及临床表现严重程度无关。更多还原

【Abstract】 Objective To determine the relationship between plasma homocysteine(Hcy) and ischemic cerebrovascular disease(ICVD)and severity of clinical manifestation.Methods Sixty-seven patients with ischemic cerebrovascular disease(ICVD),including 90 patients with cerebral infarction and 44 patients with transient ischemic attack(TIA),were enrolled using enzyme linked immunosorbent assay(ELISA),and 40 synchronization outpatients were selected as control group.The level of Hcy was detected and traditional risk factors of the patients with cerebrovascular disease were recorded,and the NIHSS score of patients with ischemic cerebrovascular disease was analyzed.In addition,this paper analyzed the relationship between Hcy and ICVD,so did the correlation between Hcy and part types and disease severity of ICVD.Results The levels of Hcy in the patients with ischemic cerebrovascular disease,cerebral infarction and TIA were higher than control group(P<0.05),but there was no difference in the level of Hcy between the patients with cerebral infarction and TIA(P>0.05).There was no relationship between level of Hcy and values of NIHSS(r=0.155,P=0.323).Hcy was brought into model by using multivariate logistic regression analysis.Conclusion Increasing Hcy may be an independent risk factor of ICVD,which has no correlation with traditional risk factors level of Hcy has no correlation with types and clinical manifestations of ICVD.更多还原