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复方参芪软胶囊对小鼠免疫功能及应激反应的影响

Effect of compound Shenqi soft capsule on immunological functions and anti-stress capability in mice

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【作者】 曹冬梅; 王春艳; 杨建春; 郑丽娜; 李云霞; 韩淑英;

【Author】 CAO Dongmei,WANG Chunyan,YANG Jianchun,et al.Tangshan Health Institute for Women and Children,Hebei,Tangshan 063000,China

【机构】 河北省唐山市妇幼保健院药剂科; 华北煤炭医学院药理教研室;

【摘要】 目的探讨复方参芪软胶囊提高免疫功能及抗应激能力的药理作用。方法复方参芪软胶囊高、中、低剂量组分别连续给健康昆明种小鼠灌胃,同时腹腔注射环磷酰胺造成免疫抑制模型小鼠,并设空白对照组,每组10只。小鼠于末次给药后30min处理,检查免疫指标及抗应激能力。结果复方参芪软胶囊对正常小鼠和免疫抑制小鼠免疫功能有一定的增强作用(P<0.05)。对正常小鼠和免疫抑制小鼠耐高温、耐低温和抗疲劳等抗应激能力也有一定的增强作用(P<0.05)。结论复方参芪软胶囊具有良好的提高免疫功能和抗应激能力的作用。

【Abstract】 Objective To investigate the pharmacological action of immune enhancement and anti-stress capability of compound Shenqi soft capsule in mice.Methods The healthy Kunming mice were given with high,middle and low dose compound Shenqi soft capsule by gavage continuously,meanwhile,immune-suppressed models were made by intraperitoneal injection with cyclophosphamide,with blank control group being set up.The immunological parameters and anti-stress ability of the mice were detected 30min after last administration.Results The compound Shenqi soft capsule could enhance the immune function both for normal rice and immune-suppressed mice (P<0.05),in addition,which could enhance the abilities of anti-stress,anti-high temperature,anti-low temperature and anti-fatigue(P<0.05).Conclusion The compound Shenqi soft capsule has the effects of increasing immune function and anti-stress ability.

  • 【文献出处】 河北医药 ,Hebei Medical Journal , 编辑部邮箱 ,2011年02期
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】98
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